RAF Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack on an hidden munitions depot in Syria employed by the Daesh militant organization, as stated by the British defence ministry.
The location, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was located in hills just north of Palmyra in Syria's central region.
"The RAF jets employed precision-guided Paveway IV munitions to strike a several access tunnels down to the depot... early reports suggest the target was engaged successfully," the ministry announced.
There was no evidence of any harm to civilians in the operation conducted Saturday night and every plane involved returned to base without incident, the ministry further stated.
The British jets were backed up by a Voyager refuelling tanker.
IS - referred to as ISIS - established jihadist rule over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows the UK's leading role, and resolve to work closely with allied nations, to eliminate any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary John Healey said.
UK warplanes have conducted surveillance missions over Syria to "prevent any efforts to regroup" of Islamic State after its routing at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of British forces involved in this strike for their expertise and their valour," he said. "They were part of numerous UK service members deployed over the festive period. This mission, to eliminate dangerous terrorists who endanger our security, demonstrates how our armed forces are prepared to act, all year round, keeping Britain secure at home and influential overseas."
Last December, the United States armed forces carried out what it described as a "massive strike" targeting Daesh sites in Syria, subsequent to an ambush claimed the lives of two US troops and a civilian interpreter in Palmyra.
The United Nations says IS still has roughly 5-7 thousand combatants in both countries.
